Functional and Structural Diversification of the Anguimorpha Lizard Venom System

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Functional and Structural Diversification of the Anguimorpha Lizard Venom System

Authors

Bryan G. Fry, Kelly Winter, Janette A. Norman, Kim Roelants, Rob J.A. Nabuurs, Matthias J.P. van Osch, Wouter M. Teeuwisse, Louise van der Weerd, Judith E. Mcnaughtan, Hang Fai Kwok, Holger Scheib, Laura Greisman, Elazar Kochva, Laurence J. Miller, Fan Gao, John Karas, Denis Scanlon, Feng Lin, Sanjaya Kuruppu, Chris Shaw, Lily Wong, Wayne C. Hodgson

Journal

Molecular & Cellular Proteomics

Publication Year

2010

Abstract

Venom has only been recently discovered to be a basal trait of the Anguimorpha lizards. Consequently, very little is known about the timings of toxin recruitment events, venom protein molecular evolution, or even the relative physical diversifications of the venom system itself. A multidisciplinary approach was used to examine the evolution across the full taxonomical range of this∼ 130 million-year-old clade. Analysis of cDNA libraries revealed complex venom transcriptomes. Most notably, three new cardioactive peptide toxin types …

Keywords

Venom Biology Lizard Snake venom Genetics Zoology Biochemistry Lizards Evolution Molecular

Categories

Academic

Tags

Venom

Regions

Australia

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Functional and Structural Diversification of the Anguimorpha Lizard Venom System